Abstract

The exact mechanistic process to be therapeutically modified towards solving the problem constituted by high mortality in very critically ill patients remains unexplored. Therefore, we avoided concepts of the phenomena in transparent animals to which the study of immunity resorted in the absence of the method by which the complexity of humans and those vertebrates that are the concern of our colleagues in veterinary healthcare may be surmounted towards a posteriori conception of the actual clinical phenomena. With the method that permitted Albert Einstein to unravel complex phenomena which were demonstrated by the Mercury problem to be beyond the reach of those senses that enabled astronomical observation, data collection and Sir Isaac Newton’s detailed data analysis of such data, we deduced the critical illness law that connects concepts of the actual phenomena to be observed in patients who are exempted from death by immunity mechanisms while others succumb. We found that individuals appear to be healthy without recovering from prior critical illnesses when these are rendered unapparent by mechanisms that permit the promotion of physical activity through adaptations that necessitate myoglobin expression towards rendering vertebrates apparently healthy. In the light of this result, we found the path on which research is to furnish the understanding of recovery towards the requisite therapies to be that on which we are to verifiably explain why fatiguing symptoms may worsen persistent illnesses towards underperformance and eventually disability following the failure of the myoglobin-dependent mechanisms of apparent health. In the light of the fact that such fatiguing symptoms that worsen with time may be followed by sudden death in patients on arrival at the hospital even without the symptoms that are expected in the absence of a posteriori concepts of the “spectral etiology theory of pathogenesis” which accommodates no more than the repeatedly proven version of the germ theory, that certain microscopic entities do exert pathological effects which may be conceived as diseases, we arrived the following conclusions. 1. The quantification of the processes by which the effects of such myoglobin-dependent mechanisms are restored is crucial to the discovery of treatments that permit effective management in non-recovering patients that even apparently healthy individuals are 2. The quantification of the processes behind the disappearance of such effects is necessary for early identification of those who, even while asymptomatic, already have severity so intensely precipitated by silently harbored microscopic entities that they may die even before arrival or even without benefiting from such treatments despite arrival if hospitalization is prompted by the severity of expected symptoms instead of the rapidity of such processes.